Shoreline Biosciences to Present Two Posters on Ink Cell Platform At 19th Meeting of The Society for Natural Immunity (NK2022)

SAN DIEGOMay 10, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced that it will present two posters at the 19th Meeting of the Society for Natural Immunity (NK2022), taking place May 14 – 17, 2022 at the Hyatt Coconut Point in Bonita Springs, Florida. Shoreline will present two posters demonstrating its novel methodologies to produce iNK cells.

“We are pleased to present our proprietary CAR-NK and iNK methodologies at the NK2022 meeting, which adds to Shoreline’s growing contribution to the advancement of the cellular immunotherapy field,” said Robert Hollingsworth, Ph.D., CSO of Shoreline. “We believe we can improve upon existing CAR-NK and CAR-T therapies with our novel approach, and we look forward to building our pipeline of iPSC-derived programs and preparing for our next steps as a clinical company.”

Details of the poster presentations are below:

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”
Poster Number: 56, Poster Session I
Date: Sunday, May 15, 2022

Title: A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”
Poster Number: 185, Poster Session II
Date: Monday, May 16, 2022

For more information, please visit the NK2022 meeting website at NK2022

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACs as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company. Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

SOURCE Shoreline Biosciences, Inc.

Shoreline Biosciences Presents Data at AACR 2022 Demonstrating its Novel Methodology to Produce Clinical Scale iPSC-derived NK (iNK) Cells

SAN DIEGOApril 12, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced the presentation of data at the American Association for Cancer Research (AACR) annual meeting in New Orleans, LA, taking place from April 8-13, 2022.  Shoreline presented two posters demonstrating its novel methodologies to produce clinical scale iPSC-derived iNK cells.

Shoreline has developed a proprietary methodology to create differentiated iNK cells for large-scale, “off-the-shelf” production.  Shoreline’s methodology supports the production of phenotypically and functionally mature iNK cells from both wildtype and genetically engineered iPSCs.  In particular, the generation of iPSC-derived NK cells bearing a knock-out of the gene encoding cytokine-inducible SH2-containing protein (CISH) was described at the AACR meeting. Shoreline’s CISH-KO iNK cells have demonstrated improved in vivo anti-tumor activity, persistence, metabolic fitness, and resistance to cell exhaustion. 

To improve the targeting and potency of its iNK cells, Shoreline has also developed a proprietary Chimeric Antigen Receptor (CAR) screening platform to identify CARs that function optimally in NK cells. Compared to CARs developed for T cells and transferred into NK cells, Shoreline’s NK-optimized CARs yield significantly increased tumor killing activity.

“The presentations at AACR 2022 on our CISH-KO iNK cells and natural killer-optimized CARs demonstrate our sophisticated expertise in iPSC differentiation, gene editing, and CAR-NK development. This technology is being applied to multiple therapeutic programs, and along with our partnerships with Kite and BeiGene, serves as the basis for our strong pipeline of novel cancer therapies,” said Robert Hollingsworth, Ph.D., CSO of Shoreline.  “Our differentiated approaches improve upon existing CAR-NK and CAR-T technologies, and we are continuing to optimize our cell therapies for potency, durability, and safety.  We are excited to advance these therapies into clinical testing and eventually provide important new options for cancer patients.”

Details of the Shoreline posters are below:

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”
Session Title: Adoptive Cell Therapy 1
Session Date and Time: Sunday April 10, 2022 1:30 PM – 5:00 PM
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 36

Title: “A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”
Abstract  Number: 4319
Session Title: Stem Cells and Regulatory Pathways in Cancer
Session Date and Time: Tuesday April 12, 2022 1:30 PM – 5:00 PM
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 12

Abstracts and full session details can be accessed through the AACR meeting planner:  AACR Annual Meeting 2022 | April 8-13, 2022 | New Orleans

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACsas allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

SOURCE Shoreline Biosciences, Inc.

Shoreline Biosciences Announces Oral Presentation on iPSC-Derived NK Cell (iNK) Platform at Innate Killer Summit Meeting 2022

San Diego, Calif., March 28, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage platforms (iMACs), today announced that management will deliver an oral presentation at the Innate Killer Summit 2022 meeting taking place in San Diego, CA from March 30-April 1, 2022. 

Details of the Shoreline oral presentation are as follows:

Title: Extending the Proliferative Capacity & Persistence of NK Cells In Vivo

Presenter: William Sandborn, MD, Co-Founder and Chief Medical Officer of Shoreline

Session Title:  Discovery: Overcoming Exhaustion & Maximizing Persistence

Date and Time:  Thursday, March 31, 2022, 11:00 AM PT

Location: Sheraton San Diego Hotel & Marina, San Diego, CA

The Innate Killer Summit is the oldest, largest, and most comprehensive industry-focused meeting, spanning discovery to phase development. The meeting cultivates innovative collaborations and forward-thinking discussions amongst scientists and business experts, all committed to advancing innate cell therapies. 

Full meeting details can be accessed through the Innate Killer Summit 2022 meeting planner:  Home | Innate Killer Summit | March 29 – April 1, 2022 | San Diego (innate-killer.com)

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and iPSC-derived macrophage platforms (iMACs).  The company’s iNK and iMACs platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com      

212-845-4271

Shoreline Biosciences Appoints Robert Hollingsworth, Ph.D., As Chief Scientific Officer

SAN DIEGOMarch 15, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage platforms (iMACs), today announced the appointment of Robert Hollingsworth, Ph.D., as its Chief Scientific Officer. 

“I am thrilled to welcome Bob as Chief Scientific Officer of Shoreline.  Bob is a proven R&D oncology leader with more than twenty-five years of experience in both small and large organizations and has advanced multiple programs to clinical development across a broad range of therapeutic modalities,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO. “We look forward to Bob driving innovation across our iNK and iMACs platforms through his deep understanding of cancer biology and cell-based immunotherapies and helping us further enhance our technologies and advance our pipeline toward the clinic.”

Dr. Hollingsworth joins Shoreline from Pfizer, Inc., where he served as Chief Scientific Officer and Vice President of Cancer Vaccines and Immunotherapeutics.  While at Pfizer, Dr. Hollingsworth led a large oncology research team who successfully advanced five programs into clinical development and implemented several innovative new therapeutic approaches.  Prior to Pfizer, he was Senior Director, Oncology Research at MedImmune where he led and advanced a large portfolio of more than twenty programs, including CAR-T programs partnered with Juno Therapeutics and the National Cancer Institute, and contributed to the approval of durvalumab (IMFINZI®).  Before that, he held several R&D positions of increasing responsibility at GlaxoSmithKline (GSK), Pharmacia and Upjohn. 

Dr. Hollingsworth is a decorated scientist with several prestigious awards and honors including the GSK Great Science Award, given to the top R&D scientist each year, and a Research Excellence Team Award at Pfizer for developing an innovative new therapy.  Dr. Hollingsworth has published over 50 papers, co-authored over 200 abstracts presented at scientific meetings, and is a co-inventor on over 15 awarded patents.  He received a B.A. in Biology and Physics from the University of California, Berkeley, a Ph.D. in Biochemistry, Biophysics, and Genetics from the University of Colorado, and was an American Cancer Society Postdoctoral Fellow at the University of Texas Institute of Biotechnology in San Antonio, Texas.    

“I am very excited to join Shoreline at a time when the company is starting to demonstrate the potential of its iNK and iMACs technology platforms and is preparing for its next steps as a clinical-stage company,” added Dr. Hollingsworth.  “I believe that Shoreline is positioned to be a category leader that will disrupt the cell immunotherapy field, and I look forward to creating meaningful new therapies to significantly improve the lives of patients with cancer.”

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and iPSC-derived macrophage platforms (iMACs).  The company’s iNK and iMACs platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com      

212-845-4271

Shoreline Biosciences to Present Multiple Posters on iPSC-Derived NK Cell Platform at AACR Annual Meeting 2022

San Diego, Calif., March 9, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (NK) cell and macrophage platforms, today announced that two of its abstracts have been accepted for presentation at the American Association for Cancer Research (AACR) annual meeting taking place April 8-13, 2022 in New Orleans, LA.

“We’re thrilled to present data on Shoreline’s innovative screening platform and methodology to discover iPSC-derived cell therapies at AACR 2022,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO.  “This is the first time we are showcasing our science at such an important scientific meeting, and we look forward to contributing to the advancement of the cell therapy space through our differentiated approach.”

Details of the poster presentations are below:

Title: “A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”

Abstract  Number: 4319

Session Title:  Stem Cells and Regulatory Pathways in Cancer

Session Date and Time:  Tuesday April 12, 2022 1:30 PM – 5:00 PM

Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 12

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”

Session Title:  Adoptive Cell Therapy 1

Session Date and Time:  Sunday April 10, 2022 1:30 PM – 5:00 PM

Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 36

Abstracts and full session details can be accessed through the AACR meeting planner:  AACR Annual Meeting 2022 | April 8-13, 2022 | New Orleans

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (NK) cell and iPSC-derived macrophage platforms.  The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com 

212-845-4271

Shoreline Biosciences Strengthens Senior Management Team With Three Key Hires

San Diego, Calif., February 15, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing our proprietary iPSC-derived natural killer (NK) cell and macrophage platforms, today announced the appointments of Lisa Melia as Vice President, Clinical Operations, Pinky Doshi as Vice President, Regulatory Affairs, and Paschalis Sideras as Vice President, Discovery Immunobiology. 

“We’re thrilled to welcome Lisa, Pinky and Paschalis to Shoreline, who bring decades of experience building and leading clinical, regulatory and discovery teams for multiple successful immunotherapy products and programs,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO.  “We look forward to leveraging their collective backgrounds as we advance our robust pipeline of cellular immunotherapies.”

New Appointment Bios

Lisa Ann Melia is a respected clinical research professional with extensive experience in the planning and execution of clinical studies from Phase 1 through Phase 3, in the US, Europe, Asia and Latin America.  Prior to joining Shoreline, Ms. Melia served as Vice President, Clinical Operations at Indaptus Therapeutics, where she was responsible for all clinical activities related to a Phase 1 first-in-human study in patients with advanced solid tumors.  Prior to that, she was Vice President, Clinical Operations for MEI Pharma, Regulus Therapeutics, and the California Institute for Biomedical Research (Calibr).  Previously, she held clinical positions at Pfizer Worldwide R&D, Icon Clinical Research, Ceregene and Acadia Pharmaceuticals.  Ms. Melia began her industry career with Boehringer Ingelheim Pharmaceuticals.  Ms. Melia holds an MA in Psychology from the University of Tennessee at Knoxville and a BA in Psychology from Trinity University.

Pinky Doshi brings to Shoreline more than two decades of global regulatory experience  within the pharmaceutical industry.  Prior to joining Shoreline, Ms. Doshi served as Senior Director, Regulatory at Bristol Myers Squibb, BMS, (formerly Celgene prior to 2019), Cell Therapy Franchise where she was the global regulatory lead on the AbecmaTM program and was the regional US lead providing strategic guidance for the first BCMA CAR T for relapsed or refractory multiple myeloma.  In addition, she served as the global regulatory lead for early and late-stage solid tumor oncology programs. Prior to BMS, Ms. Doshi served in several regulatory positions across multiple therapeutic areas in early and late-stage therapeutics at Hoffmann-La Roche, Schering Plough Research Institute, and Johnson & Johnson Pharmaceutical Research & Development.  Prior to that, Ms. Doshi held regulatory positions at Halsey Drug Company, Quest International, and TAP Pharmaceuticals.  Ms. Doshi holds a Bachelor of Science, Cell and Structural Biology from the University of Illinois and a Master of Science, Biotechnology from Northwestern University.

Paschalis Sideras brings more than three decades of global experience in immunology research within both academia and the pharmaceutical industry.  Dr. Sideras joins the company from the Academy of Athens where he served as Director of the Centre for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation.  Before that, he served in roles of increasing responsibility at AstraZeneca in the R&D team in Lund, Sweden.  Prior to AstraZeneca, Dr. Sideras served in several academic roles including Assistant Professor of Cell and Molecular Biology and Visiting Scientist where he oversaw teams of graduate students and post-doctoral fellows across many scientific disciplines.  He holds a Dr. Med. Sci. in Immunology, from the Karolinska Institute in Stockholm, Sweden and a Docent in Molecular Immunology, from Umeå University in Umeå, Sweden.

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing our proprietary iPSC-derived natural killer, or NK, cell and iPSC-derived macrophage platforms.  The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com 

212-845-4271

Shoreline Biosciences To Present At Two Upcoming Investor Conferences

SAN DIEGO, Nov. 23, 2021 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biotechnology company developing intelligently designed allogeneic off-the-shelf, standardized, and targeted induced pluripotent stem cells (iPSC) derived natural killer (NK) and Macrophage cellular immunotherapies, today announced that company management will present and conduct one-on-one meetings at the Piper Sandler 33rd Annual Healthcare Conference and the 4th Annual Evercore ISI HealthCONx Conference:

Piper Sandler 33rd Annual Healthcare Conference

  • Monday, November 29, 2021, Private Company Day
  • Pre-recorded presentation will be available on Monday, November 22, 2021 at 10 AM ET to conference attendees

4th Annual Evercore ISI HealthCONx Conference

  • Tuesday, November 30, 2021, fireside chat at 12:10 PM ET

About Shoreline Biosciences

Shoreline is dedicated to creating next-generation cellular immunotherapies for cancer that overcome the limitations of current cell therapy products.  Shoreline is advancing a pipeline of natural killer cell and macrophage-cell therapies into the clinic. Shoreline’s clinical candidates are derived from the company’s deep expertise in iPSC differentiation methods and genetic reprogramming of disease relevant pathways.  Shoreline has strategic partnerships with Kite, a Gilead Company, and BeiGene, a global biotechnology company, Contract Development and Manufacturing Organization partnerships with well-established organizations, and is supported by high-quality investors.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

 

 CONTACT: Amy Conrad, Juniper Point, amy@juniper-point.com, 858-366-3243

Dendreon Pharmaceuticals and Shoreline Biosciences Announce CMC and Manufacturing Alliance to Advance the Future of iPSC Cellular Therapy

– Partnership Focuses on Next Generation Allogeneic Cell Therapies –

SEAL BEACH, Calif. & SAN DIEGO, November 4th , 2021 – Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of cellular immunotherapy, and Shoreline Biosciences, a biotechnology company developing allogeneic off-the-shelf, standardized, and targeted natural killer (NK) and macrophage cellular immunotherapies derived from induced pluripotent stem cells (iPSC) for cancer, today announced an alliance to advance the future of iPSC-derived cellular therapies.

The alliance leverages Dendreon’s extensive manufacturing, process development and end-to-end logistics expertise for the advancement of Shoreline’s pipeline of iPSC-derived cellular therapies. Dendreon is providing scalable cGMP manufacturing support for certain programs through clinical development and launch, enabling Shoreline to rapidly advance multiple products in parallel.

“With more than a decade of proven expertise in cell therapy manufacturing and an established supply chain and logistics infrastructure, Dendreon is well positioned to support Shoreline in manufacturing from Phase I clinical trials through commercialization,” said Maria Cho, Vice President of Business Development and Corporate Strategy. “We are thrilled to partner with Shoreline to enable the future of cell therapy and change the way serious diseases are treated.”

“We are excited to partner with Dendreon, a leader in cell therapy, to manufacture cost-efficient, highly-scalable product candidates,” said Mohammad El-Kalay, Ph.D., Senior VP & Head of CMC for Shoreline.  “Through our partnership with Dendreon, we are accelerating the commercialization of our next generation NK cell and macrophage products to bring scalable, allogeneic, “off the shelf” therapies to more patients in need.”

###

About Dendreon

Dendreon is a commercial-stage biopharmaceutical company and end-to-end provider of manufacturing services for the cell therapy market. Dendreon’s flagship product, PROVENGE® (sipuleucel-T), was the first FDA-approved immunotherapy made from a patient’s own immune cells and has been prescribed to over 40,000 men in the U.S. since 2010. Dendreon is headquartered in Seal Beach, Calif. For more information about Dendreon’s contract manufacturing services division, please visit https://www.dendreon.com/Partner-With-Us.

About Shoreline’s iPSC NK cell technology

Shoreline has developed a proprietary platform focused on iPSC-derived natural killer (NK) cells and macrophages that are optimized with precise and rational genetic reprogramming. The Shoreline NK cell and macrophage-based cell therapies are designed to provide an effective and efficient means for targeting and killing tumors as well as repairing tissue homeostasis. Shoreline’s approach, based on the advantage of its iPSC cell engineering and expansion, is being used to create a streamlined, affordable, and scalable manufacturing process that can deliver cell therapy treatments to patients in a more cost-effective, time-saving manner. Shoreline’s technology is at the forefront of regenerative medicine and is being used to develop potential therapies to treat a wide range of oncology indications.

About Shoreline Biosciences

Shoreline is dedicated to creating next-generation cellular immunotherapies for cancer that overcome the current limitations of first-generation cell therapy products.  Shoreline is building a pipeline of natural killer (NK) cell and macrophage-cell therapy candidates derived from its deep expertise in iPSC differentiation methods and genetic reprogramming of disease relevant pathways.  Shoreline has strategic partnerships with Kite, a Gilead Company, and BeiGene, a global biotechnology company, and is supported by high-quality institutional investors.  Shoreline Biosciences is headquartered in San Diego, CA.

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Shoreline Biosciences Investor and Media Contact:
Amy Conrad
Juniper Point
amy@juniper-point.com
858-366-3243

Shoreline Biosciences Announces $140M Financing To Advance Pipeline Of Next Generation Cell Immunotherapies

Financing accelerates the growth of Shoreline’s pipeline of iPSC-based cell immunotherapies for the treatment of seriously ill patients and enables the buildout of smart manufacturing capabilities

SAN DIEGO, Nov. 2, 2021 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biotechnology company developing intelligently designed allogeneic off-the-shelf, standardized, and targeted induced pluripotent stem cells (iPSC) derived natural killer (NK) and macrophage cellular immunotherapies, today announced the completion of a $140M financing, led by Ally Bridge Group, with participation from new investors Eventide Asset Management, BeiGene, Irving Investors, Kingdon, NS Investment, Piper Heartland Healthcare Capital, and Superstring.  Existing investors Boxer Capital, BVF Partners, L.P., Commodore Capital, Cormorant Asset Management, Janus Henderson Investors, Kite, a Gilead Company, Stork Capital, Wedbush Healthcare Partners and an undisclosed leading global investment firm, also participated.  In connection with the financing, Frank Yu, Founder, CEO and CIO of Ally Bridge Group, joined the Shoreline Board of Directors.   

“We are proud of Shoreline’s tremendous progress over the past year, including next generation, more persistent and more effective iPSC-derived NK cells, enhancing our core technologies, advancing our preclinical programs, establishing transformative and validating partnerships with Kite and BeiGene, creating smart manufacturing methods, and attracting exceptional talent to support our next phase of development and growth,” said Kleanthis G. Xanthopoulos, Ph.D., Shoreline’s co-founder, Chairman and Chief Executive Officer. “With this financing and our corporate partnerships, Shoreline has now more than $300 million to continue building our pipeline of safe, effective and affordable cellular immunotherapies for both solid tumors and hematologic malignancies.”

“Having invested in – and followed closely for several years — the iPSC-derived NK cells-based therapeutics field which has made highly encouraging progress in the clinic, we are convinced of the true differentiation demonstrated by the Shoreline technology platform. Ally Bridge Group, a leading investor in best-in-class cell therapy companies from oncology to autoimmune diseases, expects Shoreline to be a new category leader,” said Frank Yu, Founder, CEO and CIO of Ally Bridge Group.   

The proceeds from the financing will allow Shoreline to continue the advancement of its proprietary iPSC platform focused on developing next generation natural killer (NK) cell and macrophage-cell therapies, create potent and persistent NK cell-specific Chimeric Antigen Receptors (CARs) as well as switchable CAR-NK cell engagers and macrophage-specific CARs to treat blood cancers, solid tumors, and other health conditions.   With the close of this financing, Shoreline is well-capitalized with greater than $300 million, including committed partnership R&D funding, to execute on its goals and advance its pipeline.

About Shoreline Biosciences

Shoreline is dedicated to creating next-generation cellular immunotherapies for cancer that overcome the current limitations of first-generation cell therapy products.  Shoreline is building a pipeline of natural killer cell and macrophage-cell therapy candidates derived from its deep expertise in iPSC differentiation methods and genetic reprogramming of disease relevant pathways.  Shoreline has strategic partnerships with Kite, a Gilead Company, and BeiGene, a global biotechnology company, Contract Development and Manufacturing Organization partnerships with well-established organizations, and is supported by high-quality investors.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Shoreline Biosciences Investor and Media Contact:
Amy Conrad
Juniper Point
amy@juniper-point.com
858-366-3243

Shoreline Biosciences Appoints Scott Forrest, PH.D., as Chief Business Officer

“We’re thrilled to welcome Scott to Shoreline as Chief Business Officer,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO. “Scott is a highly accomplished executive with extensive experience in building and advancing emerging biotech companies and we look forward to leveraging his background as we evolve into a leading cell therapy company.”

Prior to joining Shoreline, Dr. Forrest was Chief Financial Officer of Autobahn Therapeutics where he was responsible for corporate development, portfolio planning and financial strategy. Prior to Autobahn, Dr. Forrest served as Chief Operating Officer and Chief Financial Officer at Inception Therapeutics, a Versant Ventures discovery engine focused on building and operating transformative biotech companies. In this role, he played an integral leadership role in multiple companies including Lycia Therapeutics, Pipeline Therapeutics, Chinook Therapeutics and Ventus Therapeutics. Prior to Inception, Dr. Forrest was a Co-Founder and Vice President of Operations and Corporate Development at BlackThorn Therapeutics. Earlier, he was Vice President of Business Development at The Scripps Research Institute, where he oversaw the creation and launch of more than 15 new biotech companies and led the negotiation and management of over $200 million in corporate alliances. He also held director or board observer positions with several companies including Zyngenia, Abide, Padlock and Epic Sciences. Dr. Forrest started his career at the University of North Carolina where he led the restructuring, expansion and management of the life sciences licensing team. He also served as an entrepreneur in residence at UNC and was a central part of the successful launch of multiple startup companies such as Epizyme. Dr. Forrest holds a B.S. in biochemistry from the University of Calgary and a Ph.D. in pharmacology from the University of Virginia.

“Shoreline is a highly innovative company with a differentiated approach to creating off-the-shelf immunotherapies that overcome the limitations of first-generation cell therapy products,” added Dr. Forrest. “The company’s history of building significant alliances, coupled with its blue-chip investors, accomplished team and breadth of its platform, make this a compelling opportunity. I’m very excited to join the team and look forward to contributing to Shoreline’s growth and continued success.”

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Shoreline Biosciences Investor and Media Contact:
Amy Conrad
Juniper Point
amy@juniper-point.com
858-366-3243