Editas Medicine and Shoreline Biosciences Enter into Definitive Agreement for Shoreline to Acquire Editas’ iNK Cell Franchise and Related Gene Editing Technologies

  • Shoreline to obtain an exclusive license to SLEEK knock-in technology for iPSC-derived NK cells, an exclusive license to SLEEK for iPSC-derived macrophages in oncology and  a non-exclusive license for AsCas12a
  • Shoreline to acquire Editas Medicine’s iNK cell franchise, including EDIT-202 and certain related manufacturing technologies
  • Economics to Editas Medicine to include upfront payment, and development and commercial milestone and royalty payments

CAMBRIDGE, Mass. And SAN DIEGO, Jan. 19, 2023 – Editas Medicine, Inc. (Nasdaq: EDIT), a clinical-stage genome editing company, today announced that it has entered into a definitive agreement with Shoreline Biosciences (Shoreline) for Shoreline to license Editas Medicine’s proprietary SLEEK (SeLection by Essential-gene Exon Knock-in) and AsCas12a gene editing technologies and acquire Editas Medicine’s preclinical gene edited induced pluripotent stem cell (iPSC) derived natural killer cell (iNK) programs and related manufacturing technologies.

Shoreline Biosciences is a private biopharmaceutical company developing next-generation cellular immunotherapies based on iPSCs utilizing proprietary iNK and macrophage (iMACs) platforms.

Under the terms of the agreement, Shoreline will obtain an exclusive license to Editas Medicine’s interest in SLEEK gene editing knock-in technology for use in Shoreline’s iNK platform and for oncology in its iMACs platform, and on a non-exclusive basis for iMACs in other indications. Shoreline will also receive a non-exclusive license for the use of Editas Medicine’s engineered AsCas12a enzyme.

As part of the transaction, Shoreline will acquire EDIT-202, Editas Medicine’s preclinical multiplexed edited iNK cell medicine for the potential treatment of solid tumors, as well as an additional iNK program under development and certain related manufacturing technologies. The acquisition of the Company’s wholly owned oncology assets by Shoreline is part of Editas Medicine’s strategic portfolio reprioritization, including its focus on the development of in vivo gene edited medicines.

“The acquisition of our allogeneic iNK franchise by Shoreline is highly aligned with our strategic portfolio reprioritization, as it allows us to sharpen our efforts on advancing current clinical stage trials and focus our resources on in vivo fit-for-purpose therapeutic construction and development.” said Gilmore O’Neill, M.B., M.M.Sc., President and Chief Executive Officer, Editas Medicine. “Shoreline is a leader in developing next generation iNK and macrophage cell therapies, and we believe they are the right company to move these assets toward clinical applications.”

“Our goal is to win the war on cancer, and through this agreement with Editas, we have strategically enhanced our ability to execute upon our mission.  The addition of Editas Medicine’s novel gene editing SLEEK technology, combined with the use of a high efficiency and high fidelity proprietary CRISPR enzyme, and the other assets from Editas Medicine’s iNK franchise, strengthens our portfolio and ability to create next generation immunotherapies for patients with cancer,” said Kleanthis G. Xanthopoulos, Ph.D., Shoreline’s Chairman and CEO, Shoreline Biosciences. “We look forward to advancing our pipeline towards the clinic, including these new assets and technologies from Editas.”

Shoreline will pay Editas Medicine an upfront payment at the close of the transaction. Additionally, Editas Medicine is eligible to receive future development and commercial milestone and royalty payments for each of the iNK programs and for future programs engineered with the gene editing technologies. Evercore Group LLC served as financial advisor to Editas Medicine on the transaction.

About Editas Medicine

As a clinical-stage genome editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cas12a genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Editas Medicine is the exclusive licensee of Broad Institute and Harvard University’s Cas9 patent estates and Broad Institute’s Cas12a patent estate for human medicines. For the latest information and scientific presentations, please visit www.editasmedicine.com.

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s cellular design technologies are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACs as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety, and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company. Shoreline Biosciences is headquartered in San Diego, CA. 

Editas Medicine Forward-Looking Statements

This press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “target,” “should,” “would,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include statements regarding the expected benefits of Editas Medicine’s transaction with Shoreline, including any future payments it may receive under the agreement and the impact on its strategic portfolio reprioritization. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including: uncertainties inherent in the initiation and completion of preclinical studies and clinical trials, and clinical development of the Company’s product candidates; availability and timing of results from preclinical studies and clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products and availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption “Risk Factors” included in the Company’s most recent Annual Report on Form 10-K, which is on file with the Securities and Exchange Commission, as updated by the Company’s subsequent filings with the Securities and Exchange Commission, and in other filings that the Company may make with the Securities and Exchange Commission in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

###

Editas Medicine Contacts:

Media

Cristi Barnett

(617) 401-0113

cristi.barnett@editasmed.com

Investors

Ron Moldaver

(617) 401-9052

ir@editasmed.com

Shoreline Biosciences Contacts:

Investor Contact

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact

David Schull

Russo Partners

David.Schull@russopartnersllc.com 

212-845-4271

 

Shoreline Biosciences Announces Oral Presentation on Novel Manufacturing Method of Ink Cells at The 64th American Society of Hematology (ASH) 2022 Meeting

SAN DIEGODec. 5, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced that it will present new data on its iNK platform during an oral presentation and in a poster at the annual meeting of the American Society of Hematology 2022 (ASH 2022).  ASH 2022 will be held from Saturday, December 10, to Tuesday, December 13, 2022, in New Orleans, Louisiana.

During the oral presentation, Shoreline scientists will showcase the Company’s novel manufacturing process to support the clinical scale cGmP production of CISH knock-out iNK cells. 

“We are thrilled to showcase Shoreline’s CISH knock-out engine and our scalable manufacturing approach during our presentations at ASH 2022,” said Kleanthis G. Xanthopoulos, Ph.D., Shoreline’s Co-Founder, Chairman and CEO.  “We believe our approach holds tremendous potential to create next-generation products using iNKs that reduce the cost and complexity of conventional cell therapy approaches.” 

Robert Hollingsworth, Ph.D., Shoreline’s Chief Scientifc Officer, added, “Our goal is to win the war on cancer with our iPSC-derived iNK and iMACs and presenting our scientific progress to our peers and collaborators is crucial to Shoreline’s growth.  We want to thank the organizers at ASH for recognizing Shoreline and providing us with the opportunity to highlight our science and we look forward to advancing our pipeline towards the clinic.”

Details of the Shoreline presentations are below:

Oral Presentation:

Title: “A Novel Method for Efficient cGMP Production of Natural Killer Cells from Clonal Master Induced Pluripotent Stem Cells for Next Generation, Off-the-Shelf Cancer Immunotherapy”
Session Name: 711. Cell Collection and Processing I
Session DateSunday, December 11, 2022
Session Time4:30 PM – 6:00 PM
Presentation Time5:45 PM
Room: Ernest N. Morial Convention Center, 220-222

Authors: Davide Bernareggi, Caryn GonsalvesMax Schabla, Alejandra Gárate-Carrillo, Mohammad El-Kalay, Dan S. Kaufman, Robert Hollingsworth, Huang Zhu

Poster Presentation:

Title: “Development of Next-Generation NK Cell Optimized Chimeric Antigen Receptors (CARs) for iPSC-Derived NK Cell Therapies Targeting Both Solid and Liquid Tumors”

Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster I
Session DateSaturday, December 10, 2022
Presentation Time5:30 PM – 7:30 PM
Location: Ernest N. Morial Convention Center, Hall D

Authors:  Lee Swanson, PhD, Kenyon Lyon, Wael Tadros, PhD, Mafalda Loreti,PhD, Tammy BabinBenjamin BlairMax Schabla, PhD, Paschalis Sideras, PhD, Dan S Kaufman, MD, PhD, Robert Hollingsworth, PhD and Huang Zhu

The abstracts are available on ASH’s official website.

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s cellular design technologies are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACs as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety, and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company. Shoreline Biosciences is headquartered in San Diego, CA. 

Shoreline Biosciences Announces Appointment of Cell Therapy Manufacturing Veteran Charles Calderaro III as Chief Technical Officer

SAN DIEGOOct. 24, 2022 / — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced the appointment of Charles Calderaro III as Chief Technical Officer. Mr. Calderaro brings three decades of manufacturing and engineering experience to Shoreline, with industry-leading expertise in building and optimizing technical and manufacturing infrastructures for cell therapy products.

“Chuck is a drug manufacturing expert, highlighted by the successful creation and implementation of end-to-end manufacturing and commercial operations for Kite, a Gilead company and a leading cell therapy company. I am thrilled to welcome him to Shoreline as Chief Technical Officer,” said Kleanthis G. Xanthopoulos, Ph.D., Shoreline’s Co-Founder, Chairman and CEO. “With Chuck’s expertise and our iPSC platforms, we are well positioned to implement our planned scalable manufacturing approach, designed to reduce the cost and complexity of manufacturing and enable the development of true ‘off-the-shelf’ products for use in outpatient settings. This could lead to a significant competitive advantage as we move our iNKs and iMACs towards the clinic.”

Prior to joining Shoreline, Mr. Calderaro served as Global Head of Technical Operations for Kite, a pioneer in cell therapy development, where he was responsible for leading all aspects of Kite’s technical operations, including process development, CMC regulatory, manufacturing, quality, supply chain, engineering, and end-to-end optimization of commercial and pipeline products. While at Kite, Mr. Calderaro oversaw the manufacturing of CAR-T cell therapy products at commercial scale. Prior to Kite, Mr. Calderaro was Senior Vice President, Global Manufacturing at BioMarin Pharmaceutical, where he was responsible for the strategic oversight and leadership of a diverse international manufacturing network, which utilizes small molecule, oligonucleotide, biotechnology, and gene therapy technologies to deliver an innovative portfolio of clinical and commercial products to patients. Before that, he spent fourteen years at Genentech in roles of increasing responsibility in product management, engineering, and manufacturing. Early in his career, Mr. Calderaro spent time at Alcon, a division of Novartis, and at Aventis Behring, spanning roles in manufacturing, validation, and biopharmaceutical operations. Mr. Calderaro received a Bachelor’s degree, Electrical Engineering from the University of Notre Dame, a Master’s Degree, Nuclear Engineering from the US Naval Nuclear Power School and a Master of Business Administration from Texan Christian University.

“It is clear that a major gating factor to increasing the number of cellular immunotherapies on the market is the lack of automation in the manufacturing process. Shoreline’s smart manufacturing system holds tremendous promise to create a novel, scalable, end-to-end process, that will optimize the product quality of iPSC-derived cell therapies,” added Mr. Calderaro. “The strength of the technology and the team created a compelling opportunity for me and I look forward to creating the manufacturing system of the future, with the goal of finally winning the war on cancer and delivering benefit to patients.”

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s cellular design technologies are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACs as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety, and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company. Shoreline Biosciences is headquartered in San Diego, CA.

Shoreline Biosciences to Present Two Posters on Ink Cell Platform At 19th Meeting of The Society for Natural Immunity (NK2022)

SAN DIEGOMay 10, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced that it will present two posters at the 19th Meeting of the Society for Natural Immunity (NK2022), taking place May 14 – 17, 2022 at the Hyatt Coconut Point in Bonita Springs, Florida. Shoreline will present two posters demonstrating its novel methodologies to produce iNK cells.

“We are pleased to present our proprietary CAR-NK and iNK methodologies at the NK2022 meeting, which adds to Shoreline’s growing contribution to the advancement of the cellular immunotherapy field,” said Robert Hollingsworth, Ph.D., CSO of Shoreline. “We believe we can improve upon existing CAR-NK and CAR-T therapies with our novel approach, and we look forward to building our pipeline of iPSC-derived programs and preparing for our next steps as a clinical company.”

Details of the poster presentations are below:

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”
Poster Number: 56, Poster Session I
Date: Sunday, May 15, 2022

Title: A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”
Poster Number: 185, Poster Session II
Date: Monday, May 16, 2022

For more information, please visit the NK2022 meeting website at NK2022

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACs as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company. Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

SOURCE Shoreline Biosciences, Inc.

Shoreline Biosciences Presents Data at AACR 2022 Demonstrating its Novel Methodology to Produce Clinical Scale iPSC-derived NK (iNK) Cells

SAN DIEGOApril 12, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms, today announced the presentation of data at the American Association for Cancer Research (AACR) annual meeting in New Orleans, LA, taking place from April 8-13, 2022.  Shoreline presented two posters demonstrating its novel methodologies to produce clinical scale iPSC-derived iNK cells.

Shoreline has developed a proprietary methodology to create differentiated iNK cells for large-scale, “off-the-shelf” production.  Shoreline’s methodology supports the production of phenotypically and functionally mature iNK cells from both wildtype and genetically engineered iPSCs.  In particular, the generation of iPSC-derived NK cells bearing a knock-out of the gene encoding cytokine-inducible SH2-containing protein (CISH) was described at the AACR meeting. Shoreline’s CISH-KO iNK cells have demonstrated improved in vivo anti-tumor activity, persistence, metabolic fitness, and resistance to cell exhaustion. 

To improve the targeting and potency of its iNK cells, Shoreline has also developed a proprietary Chimeric Antigen Receptor (CAR) screening platform to identify CARs that function optimally in NK cells. Compared to CARs developed for T cells and transferred into NK cells, Shoreline’s NK-optimized CARs yield significantly increased tumor killing activity.

“The presentations at AACR 2022 on our CISH-KO iNK cells and natural killer-optimized CARs demonstrate our sophisticated expertise in iPSC differentiation, gene editing, and CAR-NK development. This technology is being applied to multiple therapeutic programs, and along with our partnerships with Kite and BeiGene, serves as the basis for our strong pipeline of novel cancer therapies,” said Robert Hollingsworth, Ph.D., CSO of Shoreline.  “Our differentiated approaches improve upon existing CAR-NK and CAR-T technologies, and we are continuing to optimize our cell therapies for potency, durability, and safety.  We are excited to advance these therapies into clinical testing and eventually provide important new options for cancer patients.”

Details of the Shoreline posters are below:

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”
Session Title: Adoptive Cell Therapy 1
Session Date and Time: Sunday April 10, 2022 1:30 PM – 5:00 PM
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 36

Title: “A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”
Abstract  Number: 4319
Session Title: Stem Cells and Regulatory Pathways in Cancer
Session Date and Time: Tuesday April 12, 2022 1:30 PM – 5:00 PM
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 12

Abstracts and full session details can be accessed through the AACR meeting planner:  AACR Annual Meeting 2022 | April 8-13, 2022 | New Orleans

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage (iMACs) platforms. The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including iNK cells and iMACsas allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

SOURCE Shoreline Biosciences, Inc.

Shoreline Biosciences Announces Oral Presentation on iPSC-Derived NK Cell (iNK) Platform at Innate Killer Summit Meeting 2022

San Diego, Calif., March 28, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage platforms (iMACs), today announced that management will deliver an oral presentation at the Innate Killer Summit 2022 meeting taking place in San Diego, CA from March 30-April 1, 2022. 

Details of the Shoreline oral presentation are as follows:

Title: Extending the Proliferative Capacity & Persistence of NK Cells In Vivo

Presenter: William Sandborn, MD, Co-Founder and Chief Medical Officer of Shoreline

Session Title:  Discovery: Overcoming Exhaustion & Maximizing Persistence

Date and Time:  Thursday, March 31, 2022, 11:00 AM PT

Location: Sheraton San Diego Hotel & Marina, San Diego, CA

The Innate Killer Summit is the oldest, largest, and most comprehensive industry-focused meeting, spanning discovery to phase development. The meeting cultivates innovative collaborations and forward-thinking discussions amongst scientists and business experts, all committed to advancing innate cell therapies. 

Full meeting details can be accessed through the Innate Killer Summit 2022 meeting planner:  Home | Innate Killer Summit | March 29 – April 1, 2022 | San Diego (innate-killer.com)

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and iPSC-derived macrophage platforms (iMACs).  The company’s iNK and iMACs platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com      

212-845-4271

Shoreline Biosciences Appoints Robert Hollingsworth, Ph.D., As Chief Scientific Officer

SAN DIEGOMarch 15, 2022 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and macrophage platforms (iMACs), today announced the appointment of Robert Hollingsworth, Ph.D., as its Chief Scientific Officer. 

“I am thrilled to welcome Bob as Chief Scientific Officer of Shoreline.  Bob is a proven R&D oncology leader with more than twenty-five years of experience in both small and large organizations and has advanced multiple programs to clinical development across a broad range of therapeutic modalities,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO. “We look forward to Bob driving innovation across our iNK and iMACs platforms through his deep understanding of cancer biology and cell-based immunotherapies and helping us further enhance our technologies and advance our pipeline toward the clinic.”

Dr. Hollingsworth joins Shoreline from Pfizer, Inc., where he served as Chief Scientific Officer and Vice President of Cancer Vaccines and Immunotherapeutics.  While at Pfizer, Dr. Hollingsworth led a large oncology research team who successfully advanced five programs into clinical development and implemented several innovative new therapeutic approaches.  Prior to Pfizer, he was Senior Director, Oncology Research at MedImmune where he led and advanced a large portfolio of more than twenty programs, including CAR-T programs partnered with Juno Therapeutics and the National Cancer Institute, and contributed to the approval of durvalumab (IMFINZI®).  Before that, he held several R&D positions of increasing responsibility at GlaxoSmithKline (GSK), Pharmacia and Upjohn. 

Dr. Hollingsworth is a decorated scientist with several prestigious awards and honors including the GSK Great Science Award, given to the top R&D scientist each year, and a Research Excellence Team Award at Pfizer for developing an innovative new therapy.  Dr. Hollingsworth has published over 50 papers, co-authored over 200 abstracts presented at scientific meetings, and is a co-inventor on over 15 awarded patents.  He received a B.A. in Biology and Physics from the University of California, Berkeley, a Ph.D. in Biochemistry, Biophysics, and Genetics from the University of Colorado, and was an American Cancer Society Postdoctoral Fellow at the University of Texas Institute of Biotechnology in San Antonio, Texas.    

“I am very excited to join Shoreline at a time when the company is starting to demonstrate the potential of its iNK and iMACs technology platforms and is preparing for its next steps as a clinical-stage company,” added Dr. Hollingsworth.  “I believe that Shoreline is positioned to be a category leader that will disrupt the cell immunotherapy field, and I look forward to creating meaningful new therapies to significantly improve the lives of patients with cancer.”

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (iNK) cell and iPSC-derived macrophage platforms (iMACs).  The company’s iNK and iMACs platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com      

212-845-4271

Shoreline Biosciences to Present Multiple Posters on iPSC-Derived NK Cell Platform at AACR Annual Meeting 2022

San Diego, Calif., March 9, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (NK) cell and macrophage platforms, today announced that two of its abstracts have been accepted for presentation at the American Association for Cancer Research (AACR) annual meeting taking place April 8-13, 2022 in New Orleans, LA.

“We’re thrilled to present data on Shoreline’s innovative screening platform and methodology to discover iPSC-derived cell therapies at AACR 2022,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO.  “This is the first time we are showcasing our science at such an important scientific meeting, and we look forward to contributing to the advancement of the cell therapy space through our differentiated approach.”

Details of the poster presentations are below:

Title: “A novel method to produce clinical scale induced pluripotent stem cell-derived natural killer (iPSC-NK) cells with improved anti-tumor activity for next-generation allogenic cell therapies”

Abstract  Number: 4319

Session Title:  Stem Cells and Regulatory Pathways in Cancer

Session Date and Time:  Tuesday April 12, 2022 1:30 PM – 5:00 PM

Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 12

Title: “Development of an iPSC-derived NK cell screening platform for discovery of NK cell optimized Chimeric Antigen Receptors (CARs) for next-generation CAR-NK cell immunotherapies”

Session Title:  Adoptive Cell Therapy 1

Session Date and Time:  Sunday April 10, 2022 1:30 PM – 5:00 PM

Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 36

Abstracts and full session details can be accessed through the AACR meeting planner:  AACR Annual Meeting 2022 | April 8-13, 2022 | New Orleans

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing its proprietary iPSC-derived natural killer (NK) cell and iPSC-derived macrophage platforms.  The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com 

212-845-4271

Shoreline Biosciences Strengthens Senior Management Team With Three Key Hires

San Diego, Calif., February 15, 2022 – Shoreline Biosciences, Inc. (Shoreline), a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells (iPSCs) utilizing our proprietary iPSC-derived natural killer (NK) cell and macrophage platforms, today announced the appointments of Lisa Melia as Vice President, Clinical Operations, Pinky Doshi as Vice President, Regulatory Affairs, and Paschalis Sideras as Vice President, Discovery Immunobiology. 

“We’re thrilled to welcome Lisa, Pinky and Paschalis to Shoreline, who bring decades of experience building and leading clinical, regulatory and discovery teams for multiple successful immunotherapy products and programs,” said Kleanthis G. Xanthopoulos, Ph.D., Chairman and CEO.  “We look forward to leveraging their collective backgrounds as we advance our robust pipeline of cellular immunotherapies.”

New Appointment Bios

Lisa Ann Melia is a respected clinical research professional with extensive experience in the planning and execution of clinical studies from Phase 1 through Phase 3, in the US, Europe, Asia and Latin America.  Prior to joining Shoreline, Ms. Melia served as Vice President, Clinical Operations at Indaptus Therapeutics, where she was responsible for all clinical activities related to a Phase 1 first-in-human study in patients with advanced solid tumors.  Prior to that, she was Vice President, Clinical Operations for MEI Pharma, Regulus Therapeutics, and the California Institute for Biomedical Research (Calibr).  Previously, she held clinical positions at Pfizer Worldwide R&D, Icon Clinical Research, Ceregene and Acadia Pharmaceuticals.  Ms. Melia began her industry career with Boehringer Ingelheim Pharmaceuticals.  Ms. Melia holds an MA in Psychology from the University of Tennessee at Knoxville and a BA in Psychology from Trinity University.

Pinky Doshi brings to Shoreline more than two decades of global regulatory experience  within the pharmaceutical industry.  Prior to joining Shoreline, Ms. Doshi served as Senior Director, Regulatory at Bristol Myers Squibb, BMS, (formerly Celgene prior to 2019), Cell Therapy Franchise where she was the global regulatory lead on the AbecmaTM program and was the regional US lead providing strategic guidance for the first BCMA CAR T for relapsed or refractory multiple myeloma.  In addition, she served as the global regulatory lead for early and late-stage solid tumor oncology programs. Prior to BMS, Ms. Doshi served in several regulatory positions across multiple therapeutic areas in early and late-stage therapeutics at Hoffmann-La Roche, Schering Plough Research Institute, and Johnson & Johnson Pharmaceutical Research & Development.  Prior to that, Ms. Doshi held regulatory positions at Halsey Drug Company, Quest International, and TAP Pharmaceuticals.  Ms. Doshi holds a Bachelor of Science, Cell and Structural Biology from the University of Illinois and a Master of Science, Biotechnology from Northwestern University.

Paschalis Sideras brings more than three decades of global experience in immunology research within both academia and the pharmaceutical industry.  Dr. Sideras joins the company from the Academy of Athens where he served as Director of the Centre for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation.  Before that, he served in roles of increasing responsibility at AstraZeneca in the R&D team in Lund, Sweden.  Prior to AstraZeneca, Dr. Sideras served in several academic roles including Assistant Professor of Cell and Molecular Biology and Visiting Scientist where he oversaw teams of graduate students and post-doctoral fellows across many scientific disciplines.  He holds a Dr. Med. Sci. in Immunology, from the Karolinska Institute in Stockholm, Sweden and a Docent in Molecular Immunology, from Umeå University in Umeå, Sweden.

About Shoreline Biosciences

Shoreline Biosciences is a biopharmaceutical company developing next-generation cellular immunotherapies based on induced pluripotent stem cells, or iPSCs, utilizing our proprietary iPSC-derived natural killer, or NK, cell and iPSC-derived macrophage platforms.  The company’s platforms are built on a deep understanding of iPSC differentiation, immune cell biology and genetic engineering that enable the development of specific effector cell types, including NK cells and macrophages as allogeneic “off-the-shelf” cellular immunotherapies designed for durability, scalability, safety and efficacy. Shoreline is advancing a pipeline of programs towards the clinic, on its own and with its strategic partners, Kite, a Gilead Company, and BeiGene, a global pharmaceutical company.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

Investor Contact:

Amy Conrad

Juniper Point

amy@juniper-point.com

858-366-3243

Media Contact:

David Schull

Russo Partners

David.Schull@russopartnersllc.com 

212-845-4271

Shoreline Biosciences To Present At Two Upcoming Investor Conferences

SAN DIEGO, Nov. 23, 2021 /PRNewswire/ — Shoreline Biosciences, Inc. (Shoreline), a biotechnology company developing intelligently designed allogeneic off-the-shelf, standardized, and targeted induced pluripotent stem cells (iPSC) derived natural killer (NK) and Macrophage cellular immunotherapies, today announced that company management will present and conduct one-on-one meetings at the Piper Sandler 33rd Annual Healthcare Conference and the 4th Annual Evercore ISI HealthCONx Conference:

Piper Sandler 33rd Annual Healthcare Conference

  • Monday, November 29, 2021, Private Company Day
  • Pre-recorded presentation will be available on Monday, November 22, 2021 at 10 AM ET to conference attendees

4th Annual Evercore ISI HealthCONx Conference

  • Tuesday, November 30, 2021, fireside chat at 12:10 PM ET

About Shoreline Biosciences

Shoreline is dedicated to creating next-generation cellular immunotherapies for cancer that overcome the limitations of current cell therapy products.  Shoreline is advancing a pipeline of natural killer cell and macrophage-cell therapies into the clinic. Shoreline’s clinical candidates are derived from the company’s deep expertise in iPSC differentiation methods and genetic reprogramming of disease relevant pathways.  Shoreline has strategic partnerships with Kite, a Gilead Company, and BeiGene, a global biotechnology company, Contract Development and Manufacturing Organization partnerships with well-established organizations, and is supported by high-quality investors.  Shoreline Biosciences is headquartered in San Diego, CA. 

For more information, please visit https://shorelinebio.com/ and engage with us on LinkedIn.

 

 CONTACT: Amy Conrad, Juniper Point, amy@juniper-point.com, 858-366-3243